![]() Our hypothesis is that the social distancing during the lockdown, uncertainty concerning the future and not least the fear of getting infected increase the stress level in the community which might trigger TGA. One patient, a 86-year-old woman, presented with coincident TGA and Takotsubo cardiomyopathy and was referred to the chest pain unit immediately. Two of the 16 patients suffered their second or third episode of TGA, respectively. None of them showed symptoms of Covid-19. 66.8 years 12 (75%) were female compared to 58% in the registry. The current TGA patients were slightly older than the more than 200 patients of our single center TGA registry with an average age of 70.8 vs. Accordingly, many stroke units recently reported lower admission rates of patients with TIA or minor strokes since the beginning of the pandemic. One might speculate that the real increase in TGA incidence was even bigger as some patients might have taken distance from presenting to an emergency department in fear of getting infected with SARS-CoV-2 there. Between February 1st and May 15th (when a loosening of the preventive restrictions came into effect because of the decline of new Covid-19 infections in Germany) we diagnosed 16 patients with TGA while the average number of patients in the same period over the last 10 years was 9.7 (SD 2.41, 95%CI 8.3–11.1). Since the Covid-19 outbreak in Germany at the end of January 2020 we have noticed an increasing number of patients with TGA in our neurological emergency department in a German academic teaching hospital. Its etiology is still a matter of debate: focal hippocampal ischemia, venous congestion, migraine- or epilepsy-like mechanisms, and metabolic stress have been hypothesized. It often occurs in the context of physical or emotional stress. ![]() The main clinical feature of transient global amnesia (TGA) is an acute anterograde memory disturbance that resolves within 24 h.
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